Editorial: Reactive oxygen species (ROS) signaling during cytoskeleton dynamics
Bibliographic record
Abstract
First, in the article "Nox1-based NADPH oxidase regulates the Par protein complex activity to 34 control cell polarization", the authors described new mechanism by which Nox-1-derived ROS 35 regulate directional cell migration. Here, cells lacking Nox1 showed reduced migration and failed to a single lamellipodium at the leading edge of cells, while the addition exogenous H2O2 or 37 Nox1 re-expression rescued this phenotype. Mechanistically, Nox1 deficiency induces PP2A 38 mislocation and inactivation, leading to increased phosphorylation and hyperactivation of the Par3, 39 aPKC, Tiam, and Rac1 polarity complex. Moreover, the authors evaluated the physiological 40 relevance of this signaling pathway using a murine model of femoral artery wire injury to generate 41 neointimal hyperplasia followed by histological analysis. Their results suggest that PP2A and aPKC 42 might contribute to reducing neointima formation observed in Nox1 We thank all the authors, editors, and reviewers who contributed to this Research Topic.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.008 |
| Meta-epidemiology (narrow) | 0.004 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.004 | 0.003 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.009 | 0.013 |
| Insufficient payload (model declined to judge) | 0.007 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".