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Record W4387491220 · doi:10.21203/rs.3.rs-3411909/v1

Efficacy and safety of local ozone injection through the surgical incision for postoperative pain in patients undergoing VATS-assisted pulmonary lobectomy:a randomized controlled trial

2023· preprint· en· W4387491220 on OpenAlexaboutno aff
Jinling Zhuang, Yuanchang Wen, Chunxiu Ling, Zhenyu Wang, Xiaoting Lai, Min Zhu, Guixi Mo, Dianqing Cao, Jing Tang

Bibliographic record

VenueResearch Square · 2023
Typepreprint
Languageen
FieldMedicine
TopicMedical and Biological Ozone Research
Canadian institutionsnot available
Fundersnot available
KeywordsMedicineVisual analogue scaleAnesthesiaPerioperativeAnalgesicRandomized controlled trialMcGill Pain QuestionnaireSurgeryAdverse effectClinical trialPostoperative pain

Abstract

fetched live from OpenAlex

Abstract Background Perioperative analgesia can improve the quality of postoperative recovery in thoracoscopic patients. Nevertheless, traditional analgesic effects are not ideal. Therefore, we intend to afford a fresh approach to managing postoperative pain in patients by dint of probe into the efficacy and safety of local ozone injection. Methods The sequence marked 87 patients subject to downwards video-assisted thoracoscopic lobectomy, divided into the ozone group (n = 44) and control group (n = 43). Primary observation indexes included the resting pain visual analog scale at 6 h, 24 h, 48 h, and 72 h as well as the postoperative three-month simplified McGill pain questionnaire. The statistical software SPSS 20.0 was used to analyse the similarity and dissimilarity in data. Results The Visual Analogue Scale scores (6 h, 24 h, 48 h, 72 h) of the ozone group after surgery were allegedly lower than those of the control group (p < 0.01). However, there were no significant differences in the sensory item score and affective item score in Pain Rating Index, Visual Analogue Scale score, or Present Pain Intensity score between the two groups in the third month after surgery (p > 0.05). Conclusions Local ozone injection for video-assisted thoracoscopic pulmonary lobectomy effectively lowers postoperative pain scores, facilitates incision healing, reduces postoperative acute adverse reactions, and enhances patients' short-term quality of life after surgery. Therefore, local ozone injection through a surgical incision is practical, safe, and feasible for postoperative pain relief in patients undergoing thoracoscopic lobectomy. Trial Registration ChiCTR2000037691(http://www.chictr.org.cn/showproj.aspx?proj=59038)registered on 30/8/2020

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.026
metaresearch head score (Gemma)0.036
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.046
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0260.036
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0010.003
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.085
GPT teacher head0.410
Teacher spread0.325 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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