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Record W4387608428 · doi:10.21203/rs.3.rs-3424524/v1

Short Communications: Assessing morphological preservation of gastrointestinal helminths in ethanol versus formalin

2023· preprint· en· W4387608428 on OpenAlexafffund
Joelle K. Hass, Megan C. Henriquez, Jessica Churcher, Hadjira Hamou, Suheidy Romero Morales, Amanda Melin

Bibliographic record

VenueResearch Square · 2023
Typepreprint
Languageen
FieldEnvironmental Science
TopicParasite Biology and Host Interactions
Canadian institutionsUniversity of Calgary
FundersAlberta InnovatesNatural Sciences and Engineering Research Council of CanadaCanada Research ChairsLeakey FoundationNational Science Foundation
KeywordsBiologyParasite hostingFecesHost (biology)ZoologyHelminthsStrongyloidesPopulationEcology

Abstract

fetched live from OpenAlex

Abstract The accurate identification of gastrointestinal parasites from animal feces is vital for understanding many aspects of host-parasite interactions. Copromicroscopic parasite identification is a longstanding, frequently used, and cost-effective method, but its efficacy depends on the storage medium of the samples. In this study we compare the preservation of parasite larvae and eggs in ethanol versus formalin-preserved fecal samples collected from a wild population of Costa Rican capuchin monkeys (Cebus imitator). Samples were collected, halved, and stored in either 10% formalin or 96% ethanol at ambient temperature, then screened for the presence of parasites using a modified Wisconsin sedimentation technique and microscopy. Parasites were morphologically identified and graded on their preservation using a rubric we developed. We identified more parasitic morphotypes in samples preserved in formalin but found no difference in counts of parasites per fecal gram between mediums. The two most prevalent genera of parasites, Filariopsis and Strongyloides, were found in similar numbers in the different mediums and while Filariopsis larvae were better preserved in formalin, strongyle eggs showed no difference in preservation between mediums. Parasites preserved in ethanol and formalin were morphologically identifiable in samples stored up to 2 years, highlighting the suitability of both mediums in morphological parasite identification. While formalin-preserved samples may not be suitable for subsequent genetic analyses, ethanol-preserved samples can be studied further using molecular methods. Future studies may build on our current understanding of parasite ecology by pairing morphological and molecular methods to explore taxonomic diversity and deepen our understanding of host-parasite relationships.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.332
GPT teacher head0.532
Teacher spread0.200 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes2
Has abstractyes

Explore more

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