Corneal changes in adult patients with progressive keratoconus after accelerated corneal cross-linking: prospective 6-month interim study results
Bibliographic record
Abstract
Aim of the study: To assess corneal densitometry (CD) and endothelium changes in adult patients with progressive keratoconus (PKC) after accelerated corneal cross-linking (A-CXL) and compare them with healthy myopic controls.Material and methods: 12 PKC patients who underwent A-CXL between 5 August 2020 and 22 March 2021 were examined and compared with 12 healthy myopes (control group).Evaluation of visual acuity, IOP, corneal topography, densitometry and specular microscopy were performed preoperatively and at the 1 st , 3 rd and 6 th postoperative month.Results: In the PKC group, a significant elevation of CD values were found in the ∅ 0-2, ∅ 2-6 zones of the anterior, central and total corneal layers after each follow-up visit.In the posterior corneal layer, they were significantly higher only in the ∅ 2-6 zone at the 6 th postoperative month.The mean CD values of myopic corneas was statistically significantly lower only in the ∅ 0-2 and ∅ 2-6 zones of the anterior, central and total layers compared with PKC-affected corneas 6 months after the A-CXL procedure.In the posterior corneal layer, the mean CD values of myopes were statistically significantly lower only in the ∅ 2-6 zone compared with baseline and 6-month post-A-CXL values.A statistically significant decrease of the endothelial coefficient of variation and increase of number of hexagonal cells was found 6 months after A-CXL in the PKC group compared with controls.Conclusions: A-CXL induces changes in corneal transparency, especially in the central 6 mm zone of anterior and central corneal stromal layers.Furthermore, transient morphological modifications in the corneal endothelium may occur following this procedure.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".