S2161 Metastatic Pancreatic Marginal Zone Lymphoma: Case Report of a Rare Diagnosis
Bibliographic record
Abstract
Introduction: Pancreatic marginal zone lymphedema is an uncommon occurrence. This case report reviews marginal zone lymphoma as it relates to its clinical presentation, diagnostic work up, and management. Case Description/Methods: A 62-year-old female with history of right breast cancer treated with lumpectomy and radiation therapy in 2018 was referred for nonspecific abdominal pain, fatigue, anemia without overt Gastrointestinal (G.I.) blood loss, and unintentional weight loss. A Computed Tomography (CT) of the abdomen revealed a 3.5 x 2.9 cm multilobulated mass in the uncinate and pancreatic head with extensive upper abdominal and mediastinal lymphadenopathy. Initial diagnostic intervention was an endoscopic ultrasound (EUS) guided Fine Needle Biopsy (FNB) of multiseptated pancreatic head measuring 5.8 cm using duodenal bulb and D2 approach was then completed. Pathology was consistent with proliferation of small lymphoid cells positive for CD20 and BCL2, consistent with low-grade B cell lymphoma. The low-grade B cell lymphoma is further defined as an extra nodal marginal zone lymphoma (MALToma). Bone marrow and aspirate immunohistochemistry were CD5 negative, CD10 negative, and indicative of monocytic lymphoproliferative disorder comprising 80% of the cellular marrow with plasmacytic differentiation overall favoring marginal zone lymphoma. Following this diagnosis, a subsequent upper GI endoscopy and biopsy was negative for H. Pylori. Following assessment by the surgical team, it was determined that due to presence of widespread lymph nodes and distant metastasis, the patient had to be referred to hematology for systemic therapy. Multidisciplinary discussion took place between representatives from hepatobiliary surgery, gastroenterology, hematology, and radiology. As a result, the patient is currently on cycle 2 of 6 of bentamustine and rituximab with consideration of cetuximab for maintenance (Figure 1). Discussion: Metastatic pancreatic B-cell marginal zone lymphoma is a rare occurrence. Accurate diagnosis and staging are crucial in determining the appropriate treatment strategy. Systemic chemoimmunotherapy plays a central role in managing metastatic disease. There’s a limited role in diagnosis and management of gastric H. Pylori infection. A multidisciplinary approach and close monitoring are essential in assessing treatment response and potential complications. Long-term follow-up is essential for detecting the disease recurrence or transformation and guiding further management decisions.Figure 1.: Endoscopic ultrasound biopsy of multiseptated pancreatic head mass.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.001 | 0.003 |
| Research integrity | 0.006 | 0.003 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".