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Record W4387789729 · doi:10.1109/mie.2023.3318831

Microinjection in Biomedical Applications: An Effortless Autonomous Omnidirectional Microinjection System

2023· article· en· W4387789729 on OpenAlexaff
Songlin Zhuang, Dongxu Lei, Xinghu Yu, Mingsi Tong, Weiyang Lin, Juan J. Rodríguez-Andina, Yang Shi, Huijun Gao

Bibliographic record

VenueIEEE Industrial Electronics Magazine · 2023
Typearticle
Languageen
FieldEngineering
TopicMicrofluidic and Capillary Electrophoresis Applications
Canadian institutionsUniversity of Victoria
FundersNational Natural Science Foundation of China
KeywordsMicroinjectionComputer scienceControl reconfigurationHuman–computer interactionControl engineeringEmbedded systemSimulationEngineeringMedicine

Abstract

fetched live from OpenAlex

Thanks to the advancements in micro- and nanomechatronics techniques, the capability to inject foreign materials into target locations inside biosamples has become increasingly crucial. However, technical problems, like orientation and penetration, make manual microinjection challenging, while most available automated platforms are too targeted and often fail to support reconfiguration for different injection tasks. In this article, we first review the state-of-the-art in microinjection techniques for biomedical applications. Then, to solve the aforementioned problems, we report an autonomous omnidirectional microinjection (AOM) system based on effortless updates of manual injection hardware with experiments. Future perspectives on the system are outlined with the possibility of multiplying daily genetic screens and the potential of widespread usage in laboratories and clinics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.727
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.003
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.231
Teacher spread0.216 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations64
Published2023
Admission routes1
Has abstractyes

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