Photosensitization Enables Pauson-Khand-type Reactions with Nitrenes
Why this work is in the frame
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Bibliographic record
Abstract
The Pauson-Khand reaction was invented in 1971, and is one of the most common pericyclic reactions in chemistry featuring the reaction of two unsaturated bonds and carbon monoxide. Even 50 years after its discovery, it remains limited to carbon monoxide as a C1 building block. Herein we report pericyclic reactions with nitrenes as a N1 unit. The reaction that comprises a non-conjugated diene and a nitrene precursor allows the rapid synthesis of bicyclic bioisosteres for common saturated heterocycles such as piperidine, morpholine, piperazine. This is achieved by relaying the diradical nature of triplet nitrene as shown experimentally and computationally. We exemplified this approach in two protocols, late-stage functionalization of drugs, and the application in drug discovery for inhibitors of soluble epoxide hydrolase.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it