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Record W4388115127 · doi:10.1016/s2352-3018(23)00233-3

Integrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration

2023· article· en· W4388115127 on OpenAlexafffund
Sophia M. Rein, Sara Lodi, Roger Logan, Giota Touloumi, Anastasia Antoniadou, Linda Wittkop, Fabrice Bonnet, Ard van Sighem, Marc van der Valk, Peter Reiss, Marina B. Klein, Jim Young, Inmaculada Jarrín, Antonella d'Arminio Monforte, Alessandro Tavelli, Laurence Meyer, Laurent Tran, M. John Gill, Raynell Lang, Bernard Surial, Andreas D. Haas, Amy C. Justice, Christopher T. Rentsch, Andrew Phillips, Caroline Sabin, José M Miró, Adam Trickey, Suzanne M Ingle, Jonathan A C Sterne, Miguel A. Hernán

Bibliographic record

VenueThe Lancet HIV · 2023
Typearticle
Languageen
FieldMedicine
TopicHIV-related health complications and treatments
Canadian institutionsAlberta Hip and Knee ClinicUniversity of CalgaryMcGill University Health Centre
FundersNational Center for Advancing Translational SciencesNational Institute of Allergy and Infectious DiseasesNational Institute on Alcohol Abuse and AlcoholismEuropean Regional Development FundStichting HIV MonitoringCenter for AIDS Research, University of WashingtonAlberta InnovatesViiV HealthcareMinisterie van Volksgezondheid, Welzijn en SportNational Institutes of HealthU.S. Department of Veterans AffairsOffice of Research and DevelopmentSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungInstitut National de la Santé et de la Recherche MédicaleInstituto de Salud Carlos IIIBill and Melinda Gates FoundationEuropean Centre for Disease Prevention and ControlDeutsches Zentrum für InfektionsforschungWellcome TrustStyrelsen för Internationellt UtvecklingssamarbeteGilead SciencesNational Institute for Health and Care ResearchCanadian Institutes of Health ResearchNational Science Foundation
KeywordsMedicineDolutegravirRegimenObservational studyClinical trialLogistic regressionViral loadIntegrase inhibitorInternal medicineCohortHuman immunodeficiency virus (HIV)Antiretroviral therapyFamily medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.015
Threshold uncertainty score0.269

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.319
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2023
Admission routes2
Has abstractno

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