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Record W4388115127 · doi:10.1016/s2352-3018(23)00233-3

Integrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration

2023· article· en· W4388115127 on OpenAlexafffund
Sophia M. Rein, Sara Lodi, Roger Logan, Giota Touloumi, Anastasia Antoniadou, Linda Wittkop, Fabrice Bonnet, Ard van Sighem, Marc van der Valk, Peter Reiss, Marina B. Klein, Jim Young, Inmaculada Jarrín, Antonella d'Arminio Monforte, Alessandro Tavelli, Laurence Meyer, Laurent Tran, M. John Gill, Raynell Lang, Bernard Surial, Andreas D. Haas, Amy C. Justice, Christopher T. Rentsch, Andrew Phillips, Caroline Sabin, José M Miró, Adam Trickey, Suzanne M Ingle, Jonathan A C Sterne, Miguel A. Hernán

Bibliographic record

VenueThe Lancet HIV · 2023
Typearticle
Languageen
FieldMedicine
TopicHIV-related health complications and treatments
Canadian institutionsAlberta Hip and Knee ClinicUniversity of CalgaryMcGill University Health Centre
FundersNational Center for Advancing Translational SciencesNational Institute of Allergy and Infectious DiseasesNational Institute on Alcohol Abuse and AlcoholismEuropean Regional Development FundStichting HIV MonitoringCenter for AIDS Research, University of WashingtonAlberta InnovatesViiV HealthcareMinisterie van Volksgezondheid, Welzijn en SportNational Institutes of HealthU.S. Department of Veterans AffairsOffice of Research and DevelopmentSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungInstitut National de la Santé et de la Recherche MédicaleInstituto de Salud Carlos IIIBill and Melinda Gates FoundationEuropean Centre for Disease Prevention and ControlDeutsches Zentrum für InfektionsforschungWellcome TrustStyrelsen för Internationellt UtvecklingssamarbeteGilead SciencesNational Institute for Health and Care ResearchCanadian Institutes of Health ResearchNational Science Foundation
KeywordsMedicineDolutegravirRegimenObservational studyClinical trialLogistic regressionViral loadIntegrase inhibitorInternal medicineCohortHuman immunodeficiency virus (HIV)Antiretroviral therapyFamily medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.073
metaresearch head score (Gemma)0.115
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.073
Threshold uncertainty score0.383

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0730.115
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.004
Bibliometrics0.0010.002
Science and technology studies0.0010.001
Scholarly communication0.0040.003
Open science0.0010.003
Research integrity0.0030.005
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.319
Teacher spread0.282 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations29
Published2023
Admission routes2
Has abstractno

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