INFLUENCE OF A PROBIOTIC BEVERAGE CONSUMPTION (Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with addition of Bifidobacterium longum ATCC 15707) IN THE ACUTE PHASE OF CHEMICALLY INDUCED COLITIS IN MICE
Bibliographic record
Abstract
Background: The ingestion of probiotic microorganisms as a nonpharmacological alternative to treating and preventing inflammatory bowel disease (IBDs), including ulcerative colitis (UC), seems to be promising, and their beneficial effects depends on the strain and the disease stage.Objective: The aim of this study was to investigate the effect of a probiotic soy product fermented with Enterococcus faecium and Lactobacillus helveticus CRL 183 416 with addition of Bifidobacterium longum ATCC 15707 in the acute phase of UC chemically induced in mice.Methods: Colitis was inducted by the administration of dextran sodium sulphate 3% in the drinking water (7 days).During the trial period (14 days), the animals were allowed in four groups (n=10): C -healthy animals; CL -animals with chemically induced colitis; CLF -animals with chemically induced colitis and receiving the probiotic fermented product; Group CLP -animals with chemically induced colitis and receiving the unfermented product (placebo).The primary end point was the disease index activity (DAI) improvement by 25% during the induction period.Secondary end points included changes histology and in the fecal microbiota composition (0.5 log CFU/g).Results: The animals treated with probiotic soy product (CLF group) showed a reduction of 30.9% in the DAI compared to CL group (p<0.05),while the animals receiving the placebo showed a non-significant reduction of 7.1%.Only the CLF group exhibited a lower degree of inflammation and ulceration, maintaining the crypt architecture.The animal of CLF group also showed a positive microbiota modulation with higher increase in the Lactobacillus spp.(1.5 log UFC/g) and less increase of enterobacteria (1.34 log UFC/g) population during the experimental protocol.Conclusions: The regular intake of probiotic fermented soy product can help in the reduction of the symptoms and preservation of colon integrity during the acute UC induced in mice.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".