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Record W4388553171 · doi:10.54254/2753-8818/8/20240363

Comprehensive research progress in stem cell therapy

2023· article· en· W4388553171 on OpenAlexaff
Ning Yuan

Bibliographic record

VenueTheoretical and Natural Science · 2023
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPluripotent Stem Cells Research
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsInduced pluripotent stem cellStem cellStem-cell therapyRegenerative medicineContext (archaeology)Regeneration (biology)MedicineMesenchymal stem cellCell therapyNeuroscienceEmbryonic stem cellBiologyPathologyCell biology

Abstract

fetched live from OpenAlex

Stem cell therapy is increasingly recognized as an innovative and transformative approach in the field of medicine, with the potential to address tissue damage and manage intricate medical conditions. The utilization of induced pluripotent stem cells (iPSCs) presents a potential avenue for cardiac regeneration in the context of cardiovascular ailments, such as myocardial infarctions. Liver regeneration techniques utilizing mesenchymal stem cells (MSCs) are being offered as potential solutions for end-stage liver failure. Furthermore, stem cell therapy is regarded as a promising intervention for neurodegenerative disorders and ocular conditions, with disease-specific induced pluripotent stem cells (iPSCs) emerging as a frontrunner in prospective therapeutic approaches. The objective of this study is to investigate the advancements made in stem cell therapy research for the diseases mentioned above. It will involve a comprehensive analysis of the mechanisms and principles underlying stem cell treatment in these areas, as well as an examination of the factors that impede the progress of stem cell therapy. Additionally, this paper will offer insights into potential future directions for development in this field.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.007
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.002
Scholarly communication0.0030.003
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0070.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.351
Teacher spread0.323 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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