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Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats

2023· article· en· W4388912128 on OpenAlexaff
David G. Harrison, Michael Bäder, Lilach O. Lerman, Gregory D. Fink, S. Ananth Karumanchi, Jane F. Reckelhoff, Rhian M. Touyz

Bibliographic record

VenueHypertension · 2023
Typearticle
Languageen
FieldMedicine
TopicAdipose Tissue and Metabolism
Canadian institutionsMcGill University Health Centre
FundersNational Heart, Lung, and Blood InstituteNational Institute on Aging
KeywordsBlood pressureMedicineMeasure (data warehouse)CuffCardiologyInternal medicineSurgeryComputer science

Abstract

fetched live from OpenAlex

blood pressure measurement; telemetry; tail-cuff; rodents; experimental hypertension Rats and mice are commonly used as experimental models in hypertension research.Critical to the field is information on blood pressure in these models at baseline, over time and following interventions.While there have been advancements in the approaches to measure blood pressure in mice and rats, the two methods that are commonly used include invasive radiotelemetry and the non-invasive tail-cuff technique.Both methods have advantages and disadvantages as highlighted in the 2005 American Heart Association statement paper on recommendations for blood pressure measurement in experimental animals. 1 Because assessment by implantable radiotelemetry allows for continuous and direct measurement of blood pressure, this has been considered as the "standard".However, with this notion is the perception by some authors and reviewers that tail-cuff measurements are not acceptable in the reporting of mouse and rat blood pressures.Here we clarify that this is not the case and that the selection of methods to be used should be informed primarily by the objectives of the study.The Editors feel it is appropriate to briefly review the methods of blood pressure

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.001
Science and technology studies0.0010.002
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0020.005
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.042
GPT teacher head0.272
Teacher spread0.230 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations32
Published2023
Admission routes1
Has abstractno

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