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Record W4388922836 · doi:10.1016/s2589-7500(23)00201-7

Large language models and their impact in ophthalmology

2023· review· en· W4388922836 on OpenAlexaff
Bjorn Kaijun Betzler, Haichao Chen, Ching‐Yu Cheng, Cecilia S. Lee, Guochen Ning, Su Jeong Song, Aaron Lee, Ryo Kawasaki, Peter van Wijngaarden, Andrzej Grzybowski, Mingguang He, Dawei Li, An Ran Ran, Daniel Shu Wei Ting, Kelvin Yi Chong Teo, Paisan Ruamviboonsuk, Sobha Sivaprasad, Varun Chaudhary, Ramin Tadayoni, Xiaofei Wang, Carol Y. Cheung, Yingfeng Zheng, Ya Xing Wang, Yih Chung Tham, Tien Yin Wong

Bibliographic record

VenueThe Lancet Digital Health · 2023
Typereview
Languageen
FieldMedicine
TopicRetinal Imaging and Analysis
Canadian institutionsMcMaster University
FundersJanssen PharmaceuticalsNational Key Research and Development Program of ChinaHealth and Medical Research FundNational Medical Research CouncilJanssen Research and DevelopmentAllerganNational Institutes of HealthCarl Zeiss Meditec AGSantenU.S. Department of AgricultureRegeneron PharmaceuticalsNvidiaNational Eye InstituteNational Institute on AgingMylanMedical Research CouncilBiogenNovo NordiskSanofiApellis PharmaceuticalsGenentechResearch to Prevent Blindness
KeywordsComputer science

Abstract

fetched live from OpenAlex

The advent of generative artificial intelligence and large language models has ushered in transformative applications within medicine. Specifically in ophthalmology, large language models offer unique opportunities to revolutionise digital eye care, address clinical workflow inefficiencies, and enhance patient experiences across diverse global eye care landscapes. Yet alongside these prospects lie tangible and ethical challenges, encompassing data privacy, security, and the intricacies of embedding large language models into clinical routines. This Viewpoint highlights the promising applications of large language models in ophthalmology, while weighing up the practical and ethical barriers towards their real-world implementation. This Viewpoint seeks to stimulate broader discourse on the potential of large language models in ophthalmology and to galvanise both clinicians and researchers into tackling the prevailing challenges and optimising the benefits of large language models while curtailing the associated risks.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.008
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.008
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0000.002
Scholarly communication0.0030.003
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.142
GPT teacher head0.467
Teacher spread0.324 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations151
Published2023
Admission routes1
Has abstractyes

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