Neurocognitive Outcome Following Tuberculous Meningitis Treatment in Adults: A Systematic Review
Bibliographic record
Abstract
Abstract Background Tuberculous meningitis (TBM) is an infectious diseases of the central nervous system that are still a global health challenge, including Indonesia. Patients who survive after experiencing TBM have a risk of functional, neurocognitive and psychological disorders that will affect daily activities. The aim of this study is to present a comprehensive review of data on neurocognitive outcome after TBM infection in adults. Method We conducted a systematic literature search to identify studies addressing cognitive outcomes in adult TBM patients. Following a systematic literature search (Pubmed, Scopus, Ebsco), studies underwent duplicate screening by independent reviewers to assess eligibility for inclusion. Three independent reviewers extracted data from included studies. Result Among the article identified, 7 studies met our inclusion criteria, reporting on cognitive outcomes for 364 adults with TBM. All studies followed the patients for 12 months or more. Three studies used Mini-Mental State Examinations (MMSE) to assess cognitive function, while other studies used a variety of tools: HIV-associated neurocognitive disorder (HAND), Montreal Cognitive Assessment (MoCA), neuropsychological (NEUROPSI), and Wechsler Adult Intelligence Scale (WAIS). All studies reported an improvement in cognitive function after completion of TB therapy. Two studies comparing TBM with HIV, and showed TBM patients with HIV had worse cognitive outcomes than those without HIV. Conclusion Cognitive function assessment tools in TBM patients are diverse and after approximately 12 months of follow-up in patients on TB therapy, there was improvement in cognitive function. Standardized reporting of neurocognitive outcomes will be essential to improve data quality and data-sharing potential.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.006 | 0.003 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".