Post‐prandial glycemic and insulin response to VERSAFIBE&[trade] 2470 dietary fiber in healthy adults
Bibliographic record
Abstract
VERSAFIBE™ 2470 dietary fiber is a resistant starch type 4 derived from high‐amylose maize. This product is high in dietary fiber (70% TDF, AOAC 2009.01 method) and can be used in a variety of bakery applications. The objective of this study was to investigate the effect of VERSAFIBE 2470 dietary fiber on the glycemic response of healthy adults (n=28). This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki and approved by the Institutional Review Board (IRB Services, Aurora, Ontario). All subjects provided informed consent prior to enrolling in the study. The primary outcome was the two‐hour (baseline to 120 min) intravenous blood glucose incremental area under the curve (iAUC 0‐120min ) after consuming a muffin top made with VERSAFIBE 2470 dietary fiber (11.6 g TDF, treatment) or a muffin top made with conventional refined wheat flour (0.9 g TDF, control). The muffin tops were matched for total weight, total carbohydrate, sugars, protein, and fat. Subjects were randomly assigned the treatment order. During each 24‐hour study period, subjects consumed a standard evening meal, fasted for 12 hours, and arrived at the study clinic the following morning. Serum glucose, serum insulin, and capillary glucose were measured at 0 min, 15 min, 30 min, 45 min, 60 min, 90 min, 120 min, 180 min and 240 min after muffin top consumption. Breath hydrogen and methane concentrations were measured at 1, 2, 3, 4 and 24 hrs. The subjects completed a seven day washout between treatments. Product perception (sensory evaluation and overall liking) was similar between the two treatments. Consumption of the VERSAFIBE™ 2470 dietary fiber muffin top resulted in a significant 33% reduction in post‐prandial serum glucose iAUC 0‐120min and an 8% decrease in maximum glucose concentration (C max 0‐120min ) versus the control muffin (p = 0.037, p= 0.007 respectively). Correspondingly, consumption of the VERSAFIBE™ 2470 dietary fiber muffin top reduced post‐prandial serum insulin iAUC 0‐120min by 38% versus the control muffin (p < 0.001). Capillary glucose iAUC 0‐120min did not differ between treatments. Serum glucose, serum insulin, and capillary glucose values were significantly lower at individual time points when the VERSAFIBE 2470 dietary fiber muffin top was consumed versus the control muffin top. There were no differences in breath hydrogen or breath methane after consumption. This study demonstrates that inclusion of a practical dose of dietary fiber (11.6 g TDF) from VERSAFIBE 2470 dietary fiber in a bakery product significantly reduced postprandial glucose and insulin responses in healthy adults. Support or Funding Information This study was funded by Ingredion Incorporated, Bridgewater, NJ, USA. Copyright 2016 by Ingredion Incorporated
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".