Vitamin D status and anthropometric measurements of children with Juvenile Idiopathic Arthritis compared to healthy children using the Canadian Health Measures Survey
Bibliographic record
Abstract
Background Nutritional impairment can be a factor that contributes to reduced growth in children with Juvenile Idiopathic Arthritis (JIA). One nutrient that might influence growth and be considered in the management of JIA is vitamin D. Objective To evaluate vitamin D status and growth parameters in children with JIA compared to healthy children. Methods Data from the Canadian multicenter Biologically Based Outcome Predictors (BBOP) study in JIA (n=136) and the Canadian Health Measures Survey (CHMS, n=3,201,735) were used. BBOP data from children, aged 6–16 years with new onset JIA, were compared to age‐matched healthy children from CHMS cycle 1 and 2 for 25(OH)D concentrations, supplement use, milk intake, season of birth, height, weight and BMI z‐scores (age and sex specific). Means and 95% confidence intervals were calculated to determine significance. Results Mean 25(OH)D status was significantly higher for JIA patients (79 ± 3.1 nmol/L vs. 68 ± 1.8 nmol/L) who reported use of a supplement with vitamin D more often (50% vs. 7% p <0.05). The prevalence of 25(OH)D deficiency (<30 nmol/L) was 6% for both groups. Children with JIA were more significantly likely to be born in the fall (JIA: 29 ± 3.9 % healthy: 22 ± 1.2 %) and winter (JIA: 33 ± 4.0%, healthy: 24 ± 1.2 %) compared with healthy children who were significantly more likely to be born in the spring (healthy: 27 ± 1.2% JIA: 19 ± 3.4% p<0.05) and summer (healthy: 27 ± 1.5% vs. JIA; 19 ± 3.4%). The proportion of children in each BMI class did not differ between the two groups. Weight and height z‐scores were significantly higher in healthy children (weight: 0.57 ± 0.05 vs −0.12 ± 0.16, height: 0.31 ± 0.04 vs. −0.11 ± 0.10). Daily milk intake was associated with a significantly higher 25(OH)D status (JIA: 86 ± 5.0 nmol/L vs. 70 ±1.8 nmol/L, healthy: 74 ± 5.2 nmol/L vs. 60 ± 2.3 nmol/L). Conclusion Children with JIA are shorter and weigh less than healthy children. Vitamin D, which was adequate in the JIA population, is not likely to be a factor accounting for impeded growth. Season of birth may reflect vitamin D status in utero or during the first few months of life. Further research into what role vitamin D status plays in the development and progression of JIA is required. Support or Funding Information Funding provided by the Children's Hospital Foundation of Saskatchewan http://medicine.usask.ca/BBOPStudyTeam.pdf
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".