1729. Literature Review to Identify Evidence of Secondary Transmission of ROTATEQ® (RV5) Vaccine Strains to Unvaccinated Subjects
Bibliographic record
Abstract
Abstract Background Rotavirus (RV) is the leading cause of severe diarrhea in infants and young children. RV vaccination is recommended by WHO since 2009 for all children worldwide, especially in countries with a high number of diarrhea-associated deaths. Live attenuated vaccines can lead to horizontal transmission with the risk of vaccine-derived disease in contacts. Transmission of RV5 strains leading to clinical disease was not well evaluated in the pivotal clinical trials and only few case-reports have been described in the literature. Methods We performed a systematic literature review to investigate secondary transmission of RV5 vaccine strains to unvaccinated subjects globally. We searched Embase, Medline for English papers, CNKI, Wan Fang for Chinese papers and other resources (i.e., conference papers with full text, preprint platform including bioRxiv and medRxiv) from January 2005 to June 2021. Eligibility criteria for inclusion were original articles bases on non-interventional studies (case-control studies, cohort studies, cross-sectional studies) using RV5 vaccine strain transmission as outcomes. Other study or publication types were excluded such as pre-clinical studies, interventional studies and case reports. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used and study quality was assessed using the Newcastle Ottawa Scale (NOS) for cohort studies and the JBI checklist for cross-sectional studies to assess risk of bias. Results The search generated 2,089 articles in total. Seven articles met all inclusion criteria, including six cohort studies and one cross-sectional study. All studies underwent quality assessment and complied with the quality criteria of NOS or JBI checklist respectively. Overall, none of the seven studies identified RV5 vaccine-type transmission to an unvaccinated population, in either hospitals or nurseries under a close contact environment. One study reported that 1% of unvaccinated infants had gastrointestinal symptoms but all symptoms were attributed to other clinical conditions. Conclusion We found no evidence of horizontal transmission of RV5 vaccine virus strains to unvaccinated infants despite the limited amount and descriptive nature of the identified studies. Disclosures All Authors: No reported disclosures
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.010 | 0.041 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.010 | 0.008 |
| Bibliometrics | 0.033 | 0.029 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.004 |
| Open science | 0.003 | 0.003 |
| Research integrity | 0.003 | 0.001 |
| Insufficient payload (model declined to judge) | 0.034 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".