Function of the Ang II system during the ontogeny of Archosaurs
Bibliographic record
Abstract
Development of cardiovascular regulation in embryonic birds and reptiles has become an area of growing interest over the past 20 yrs. Embryonic cardiovascular control is predominantly dependent on humoral mechanisms across these vertebrate groups. This is evident in the absence of autonomic tone in many species of birds and reptiles, as well as elevated levels of circulating catecholamines. In addition to circulating catecholamines, other humoral regulators have been identified to contribute to baseline regulation of the embryonic cardiovascular system, including angiotensin II (Ang II). Initial work has illustrated that in two representative, extant archosaurs, the domestic chicken ( Gallus domesticus ) and the American alligator, Ang II produces a dose dependent increase in arterial pressure that is mediated, in part by alpha‐adrenergic receptor stimulation. While the agonist produced a clear cardiovascular response in these species, the response is unaltered by known Ang II receptor antagonists. Direct inhibition was unsuccessful, but indirect manipulation of the Ang II system by decreasing angiotensin converting enzyme function produced noted reductions in arterial pressure, altered organ system size, and altered baroreflex function. This suggests Ang II is an important tonic regulator of cardiovascular function in Archosaurs during development. Support or Funding Information NSF CAREER award IBN IOS‐0845741 to Dane A Crossley II
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".