The Modifications That Arise in The Thyroid Hormone in Prediabetic Patients Above 18 Years of Age: Protocol for A Systematic Review (Preprint)
Bibliographic record
Abstract
Background: Prediabetes is a condition of intermediate hyperglycaemia below the diagnostic threshold of type 2 diabetes mellitus.Recent studies have found that the most prevalent endocrine illnesses are thyroid dysfunction and type 2 diabetes melittus which have a bidirected influence upon each other.Objective: This systematic review protocol will deliver an outline of all procedures in the synthesis of the available data on the changes in thyroid hormone concentrations.Methods: This protocol was prepared in accordance with the PRISMA 2020 guidelines for reporting protocols.Published prospective observational studies, case-control, cohort, and cross-sectional studies designs that involve non-diabetic, type 2 diabetes and pre-diabetes reports will be used.The databases that will be screened are MEDLINE, Google Scholar, PubMed, Embase and African Journals Online.Three reviewers (HA, AK, WM) will screen all the results for eligibility criteria.The risk of bias will then be examined using the STROBES checklist.Review Manager v5.4 Forrest plot will be used for meta-analysis and sensitivity analysis.The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach will then be used to grade the quality of the evidence. Results:The systematic review will make use of publicly accessible data, which will be gathered after the release of this protocol.This protocol will give direction on the exploration of articles that report on changes in thyroid hormone concentrations in the pre-diabetic state. Conclusions:The results obtained from this protocol will further give direction on the research to be done at in the eThekwini district of South Africa.Clinical Trial: International Prospective Registry of Systematic Reviews (PROSPERO) CRD42023430297, https://www.crd.york.ac.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.088 | 0.164 |
| Meta-epidemiology (narrow) | 0.006 | 0.006 |
| Meta-epidemiology (broad) | 0.018 | 0.020 |
| Bibliometrics | 0.011 | 0.010 |
| Science and technology studies | 0.004 | 0.005 |
| Scholarly communication | 0.009 | 0.009 |
| Open science | 0.005 | 0.005 |
| Research integrity | 0.010 | 0.008 |
| Insufficient payload (model declined to judge) | 0.076 | 0.011 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".