MétaCan
Menu
Back to cohort
Record W4389245985 · doi:10.1002/jvc2.v2.4

Predicting discontinuation of biologic therapy caused by adverse events in psoriasis patients—A Danish nationwide cohort study

2023· paratext· en· W4389245985 on OpenAlexaff
Mia‐Louise Nielsen, T. C. Petersen, Julia‐Tatjana Maul, Jashin J. Wu, Trine Bertelsen, Lone Skov, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg

Bibliographic record

VenueJEADV Clinical Practice · 2023
Typeparatext
Languageen
FieldMedicine
TopicDermatology and Skin Diseases
Canadian institutionsInstitute of Particle Physics
FundersJanssen PharmaceuticalsLEO PharmaHorizon TherapeuticsCilagMylanUCB PharmaKongelig Hofbuntmager Aage Bangs FondRegeneron PharmaceuticalsSanofiSimon Spies FondenLes Laboratories Pierre FabreCelgeneGaldermaAstraZenecaBristol-Myers SquibbEli Lilly and CompanyPfizerNational Psoriasis FoundationAmgen
KeywordsDiscontinuationPsoriasisMedicineAdverse effectDanishDermatologyCohortDrugInternal medicinePharmacology

Abstract

fetched live from OpenAlex

Depiction of Franz cell experiments and clinical application protocols of Dermovate cream with emollients, where the products are applied sequentially after 5 or 30 min. Hypothesised formulation effects on drug delivery are illustrated, showing a mixed Dermovate cream—emollient system on the skin surface and layering of the formulations causing barrier and occlusive effects. The clinical application protocols reducing drug delivery to human skin is shown, with larger decreases usually occurring when the emollient was applied before Dermovate cream.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.035
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.133
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.035
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.056
GPT teacher head0.422
Teacher spread0.366 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

Explore more

Same venueJEADV Clinical PracticeSame topicDermatology and Skin DiseasesFrench-language works237,207