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Record W4389453178 · doi:10.3138/jammi-2023-05-08

Highly pathogenic avian influenza: Unprecedented outbreaks in Canadian wildlife and domestic poultry

2023· article· en· W4389453178 on OpenAlexafffundvenueabout
Christian Renaud, Andrea Osborn, E. Jane Parmley, Todd F. Hatchette, Jason J. LeBlanc, J. Scott Weese, Vikram Misra, Deborah Yamamura, Sarah Forgie, Shane A. Renwick, Duncan Webster, Samira Mubareka

Bibliographic record

VenueJournal of the Association of Medical Microbiology and Infectious Disease Canada · 2023
Typearticle
Languageen
FieldMedicine
TopicInfluenza Virus Research Studies
Canadian institutionsUniversity of TorontoSaint John Regional HospitalCanadian Veterinary Medical AssociationMcMaster UniversityNova Scotia Health AuthorityCanadian Medical AssociationCanadian Food Inspection AgencyUniversity of AlbertaUniversité de MontréalUniversity of SaskatchewanUniversity of Guelph
FundersNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchCanadian Immunization Research NetworkNational Institutes of HealthGenome AtlanticAssociation of Medical Microbiology and Infectious Disease CanadaSanofi
KeywordsInfluenza A virus subtype H5N1OutbreakHighly pathogenicWildlifeVirologyGeographyPoultry farmingBiologyVeterinary medicineMedicineEcologyVirus

Abstract

fetched live from OpenAlex

Canada experienced a wave of HPAI H5N1 outbreaks in the spring of 2022 with millions of wild and farmed birds being infected. Seabird mortalities in Canada have been particularly severe on the Atlantic Coast over the summer of 2022. Over 7 million birds have been culled in Canada, and outbreaks continue to profoundly affect commercial bird farms across the world. This new H5N1 virus can and has infected multiple mammalian species, including skunks, foxes, bears, mink, seals, porpoises, sea lions, and dolphins. Viruses with mammalian adaptations such as the mutations PB2-E627K, E627V, and D701N were found in the brain of various carnivores in Europe and Canada. To date this specific clade of H5N1 virus has been identified in less than 10 humans. At the ground level, awareness should be raised among frontline practitioners most likely to encounter patients with HPAI.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.008
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.373
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.008
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.290
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2023
Admission routes4
Has abstractyes

Explore more

Same venueJournal of the Association of Medical Microbiology and Infectious Disease CanadaSame topicInfluenza Virus Research StudiesFrench-language works237,207