Sex differences in mouse placental metabolite profiles: an NMR metabolomics study
Bibliographic record
Abstract
A proper functioning placenta is essential for normal fetal development. The placenta has a vital function as a protective barrier and is critical for nutrient and waste exchange for the developing fetus. Our group and others have reported sex differences in both placental structure and function; however, differences in the placental metabolome between female and male fetuses have been understudied. Here, placental tissue samples were collected from healthy pregnant CD-1 mice in late gestation ( n = 26 female and n = 27 male placentas from 17 dams at embryonic day 17.5). Metabolite profiles were determined using 1H magic angle spinning nuclear magnetic resonance. The relative concentration of alanine was significantly higher in male placentas whereas, threonine was higher in female placentas ( p < 0.05). This study adds to the growing literature demonstrating sex differences in healthy placental function and emphasizes the importance of examining both female and male placentas in metabolomics studies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".