A fully-flexible and thermally adjustable implantable neural probe with a U-turn polyester microchannel
Bibliographic record
Abstract
This work presents a fully flexible implantable neural probe fabricated with Polydimethylsiloxane (PDMS) and including a thermally-tunable stiffness microchannel filled with Polyester. The probe includes an optimized microfluidics mixer for drug delivery. Polyester, which is solid at room temperature and has a low melting point close to body temperature, is used to decrease the stiffness of the probe after insertion, after getting in contact with tissues. We designed a U-turn microchannel inside the PDMS neural probe and filled it up with melted polyester. The microchannel has a cross-section of 30 μm × 5 μm and a length of 14.7 mm. The following probe dimensions were chosen after extensive simulation: thickness = 20 μm, width = 300 μm, and length = 7 mm. These values yield a buckling force above 1 mN, which is sufficient for proper insertion into the brain tissues. Simulation results show that the microfluidics mixer with a cross-section of 90 μm × 5 μm and a length of 7 mm has optimum performance for the desired flow rate and quantity of drug to deliver. The pressure drop inside the microfluidic channel is less than 0.43 kPa, which is appropriate for PDMS-PDMS bonding, whereas the Reynolds number is near 1.91k in the laminar regime. No leakage or bubble occurred during the experimental validation, which suggests an appropriate pressure and a laminar flow in the channel.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".