S81 Variables Associated With Fatigue in Patients With Crohn’s Disease
Bibliographic record
Abstract
Background: Fatigue in Crohn’s disease (CD) is debilitating and costly for the patient and healthcare system. It does not have well-established therapies, and it is important to investigate risk factors and, therefore, collaborate to prevent or reduce symptoms. Objective: To investigate variables associated with fatigue in outpatients with Crohn’s disease undergoing pharmacological treatment. Methods: Cross-sectional study, carried out at the IBD outpatient clinic of Hospital Geral Roberto Santos (HGRS), approved by the Ethics and Research Committee of the Roberto Santos General Hospital - registration 5,681,087. Inclusion criteria: being an HRGS patient; CD diagnosis; 18 years or older; use medications for CD. Exclusion criteria: condition that limits the ability of pregnant women to respond to the questionnaires. Data collection: sociodemographic profile, Montreal, Harvey and Bradshaw Index, Inflammatory Disease Questionnaire – Fatigue (IBD-F), Visual Analogue Fatigue Scale (VAS) and Depression, Anxiety and Stress Scale. All statistical analyzes were performed in SPSS version 21.0. Results: 84 patients were included in this first phase of the research, 59.5% of whom were female. Mean age 40.17 years (SD 13.26). Of these patients, only 5 (6%) were diagnosed with diabetes mellitus and 4 (4.8%) were diagnosed with asthma. The predominant location of CD was in the colon (42.9%) and the predominant behavior was non-stenosing, non-penetrating (38.1%). According to IBD-F, 67 (79.8%) of the patients presented fatigue, 23 (34.3%) were male and 44 (65.7%) were female. The mean fatigue intensity according to the VAS was 5.59 (SD 1.94). Regarding pharmacological treatment, the most used medications were infliximab (44 patients, of which 86.36% have fatigue, p = 0.226), azathioprine (29 patients, of which 86.20% have fatigue, p = 0.662) and adalimumab (21 patients, of which 71.43% have fatigue, p= 0.272). Of the 67 patients with fatigue, 55.2% had insomnia (p= 0.001), 41.8% had symptoms of depression (p=0.001) and 49.3% had anxiety (p=0.005) and 47.8% had symptoms of stresses (p=0.002). 48 patients (74.6%) had the disease in remission, and 81.25% of them had fatigue (p=0.504). 20 patients had active disease and of these 85% had fatigue. Among the 67 patients with fatigue, 28 (41.8%) (p=0.166) underwent surgeries related to CD. Fatigue intensity (VAS) among patients with remission was 5.44 (SD 1.86) and among active disease 5.94 (SD 1.96). Conclusions: The prevalence of fatigue is high. Regarding the variables associated with fatigue in patients with CD, the following stand out: insomnia, depression, anxiety and stress.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".