A SYSTEMATIC REVIEW TO DETERMINE THE ROLE OF ERYTHROPOIETIN IN PREVENTION OF HYPOXIC ISCHAEMIC ENCEPHALOPATHY OF NEWBORN
Bibliographic record
Abstract
Background :Hypoxic Ischaemic Encephalopathy (HIE)secondary to perinatal ischemia is an important cause of brain damage in newborn .Hence all efforts to prevent hypoxic damage is a must along with the attempts to correct the associated abnormalities .Hypoxia has long been known to trigger the release of Erythropoietin which stimulates the production of red blood cells in order to increase the oxygen carrying capacity of blood. It possesses positive neuroprotective, neuro-regenerative and anti-inflammatory effects in asphyxiated newborns Hence the interest in the role of Erythropoietin in HIE for a long time .Yet Erythropoietin has not been standardized as therapeutic guideline in the management of HIE. In addition the role of Hypothermia has also evolved and is now the only available and standard option . But this choice is till today not available for the majority of neonates due to financial constraints and the dearth of proper Therapeutic Hypothermia facilities. So this study was done to determine whether Erythropoietin is a boon or not for Neonatal HIE. Objective: Assessment of Role of Erythropoietin in prevention of HIE in newborn. Data Sources : A detailed search in PubMed, Embase, and Cochrane databases for studies involving the role of Erythropoietin in HIE in newborn infants was done till 08.11.23. Ultimately, 11 studies were selected . Study selection: Only those studies were included which were delivered in tertiary care centres and were administered Erythropoietin at or few hours after birth.Three studies were Randomized control trials with the recent one in 2023 with an updated Meta Analysis, three were from the HEAL Trial and five were reviews .First one was done in 2019(S.Arabia,canada and India),2021(2 studies China) and 2022(2 studies one from Italy and One from Korea). Data Extraction :Eleven studies were assessed and various data noted for each of these studies like Author ,Year of study, type of study ,place of study, number of participants involved and their conclusions ,participants, gestation age, birthweight, EPO administration method (dose, frequency and course), hypothermia therapy given or not. Subsequently the outcome was noted. Conclusions : HIE in newborn is a serious problem and needs to be prevented at all costs. Further the problem varies as the gestational age varies. Epo has a role to play as evidenced by the innumerable studies done on the term and preterm babies . Further research on the preventive role in prematurity needs to be investigated.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.025 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.010 | 0.008 |
| Bibliometrics | 0.011 | 0.011 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.009 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".