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Record W4390142083 · doi:10.21203/rs.3.rs-3731579/v1

Chemotherapy and COVID-19: Impact on Health, Strength, and Cardiovascular Risk in Cancer Patients

2023· preprint· en· W4390142083 on OpenAlexaff
Giérisson Brenno Borges Lima, Gabriel Santos Castro e Lima, Flaviana Santos Sousa Silva, Luís Felipe Castro Araújo, Thaynan Piontkovsky Pereira, Michel Macedo Monteiro, Thiago dos Santos Rosa, Hugo de Luca Corrêa, Carlos Eduardo Neves Amorim

Bibliographic record

VenueResearch Square · 2023
Typepreprint
Languageen
FieldMedicine
TopicBody Composition Measurement Techniques
Canadian institutionsRedeemer University
Fundersnot available
KeywordsMedicineAnthropometrySarcopeniaWaistBody mass indexChemotherapyWaist–hip ratioCancerInternal medicinePhysical therapy

Abstract

fetched live from OpenAlex

<title>Abstract</title> <bold>Objective:</bold> To evaluate and describe the phase angle profile and anthropometric health and fitness indicators of patients undergoing chemotherapy. <bold>Materials and Method:</bold> The sample included 106 adult and elderly cancer patients, with different types of cancer, undergoing chemotherapy treatment, of both sexes (71 women and 35 men). They underwent anthropometric assessment, tetrapolar bioimpedance, anthropometry, handgrip dynamometry and the international physical activity questionnaire (IPAQ). <bold>Results:</bold> After the analysis, the Body Mass Index (BMI) showed that 49% had changes in ideal body mass indices (13% below and 36% above ideal). The waist-to-hip ratio of most patients (63.7%) indicated a high (36.4%) and very high (27.3%) risk of developing cardiovascular diseases, with only 27.3% being moderate and 9.1% Low %, with higher risk values in women. In body composition, 62.9% of patients showed important changes in body fat percentage (22.9% below and 35% above recommended), in addition to the high prevalence of reduction in skeletal muscle mass, reaching 76% of those evaluated, indicating possible development of sarcopenia, being more evident in women. The majority of patients also had inadequate strength levels (63.6%), both men and women. Men are approximately 4 times more likely to have an insufficient level of strength. The phase angle with an average below the recommended level was found in 94.8% of the sample. The level of physical activity assessed demonstrated 100% sedentary lifestyle. <bold>Conclusion:</bold> With the investigation of the variables proposed in this study, we concluded that patients undergoing chemotherapy during the COVID-19 pandemic period had an insufficient level of physical activity, an inadequate level of muscle strength, anthropometric indices and body composition with negative changes, increased cardiovascular risk and low phase angle of reference values in the majority of the sample, with women having the most unfavorable profile. The research project was approved by the institutional review board, no. 5.069.269.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.121
Threshold uncertainty score0.987

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.126
GPT teacher head0.479
Teacher spread0.353 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2023
Admission routes1
Has abstractyes

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