Frontline Ethico-legal Issues in Childhood Cancer Genetics Research
Bibliographic record
Abstract
Clinical research involving child participants frequently raises both legal and ethical concerns that researchers, clinicians and parents must navigate in order to pursue relevant pediatric-centered investigation in health, and particularly in cancer care. The foundational ethico-legal principles governing research participation provide the necessary frameworks with which to evaluate how emerging genetic technologies can serve current and future childhood cancer research. Taking the best interests of the child as the primary consideration in all decisions affecting a child, this chapter explores issues regarding consent/assent and return of results in pediatric oncology research. With a primary focus on Canada, the USA, and Europe, we examine the issues presented by the use of next-generation sequencing, pharmacogenomics, and biobanking and data sharing in international consortia.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.021 | 0.043 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.007 | 0.014 |
| Scholarly communication | 0.011 | 0.007 |
| Open science | 0.001 | 0.004 |
| Research integrity | 0.011 | 0.008 |
| Insufficient payload (model declined to judge) | 0.042 | 0.016 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".