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Record W4390374510

Effect of mouse nerve growth factor combined with mecobalamine on treatment of diabetic peripheral neuropathy

2016· article· en· W4390374510 on OpenAlexaboutno aff
De-Rong Hu

Bibliographic record

VenueDOAJ (DOAJ: Directory of Open Access Journals) · 2016
Typearticle
Languageen
FieldMedicine
TopicBotulinum Toxin and Related Neurological Disorders
Canadian institutionsnot available
Fundersnot available
KeywordsPeripheral neuropathyMedicineNerve growth factorDiabetic neuropathyPeripheralDiabetes mellitusInternal medicineEndocrinologyReceptor
DOInot available

Abstract

fetched live from OpenAlex

Objective: To observe the clinical effect of mouse nerve growth fact (NGF) combined with \nmecobalamine on treatment of diabetic peripheral n-europathy (DPN). Methods: A total of \n84 cases of patients with DPN treated in ourhospital between April 2012 and June 2015 were \nselected, and divided into study group and control group randomly (n=42); Control group \nwas only given mecobalamine treatment, while study group was given mouse nerve growth \nfactor combined with mecobalamine treatment for 4 weeks. TThe motor nerve conduction \nvelocity median nerve (MNCV), sensory nerve conduction velocity (SNCV), serum high \nsensitivity c-reactive protein (hs-CRP) and Toronto clinical scoring system (TCSS) changes \nof median nerve and nervus peroneus communis before and after treatment were compared. \nResults: There were no significant differences in MNCV, SNCV of mediannerve and nervus \nperoneus communis before treatment. MNCV and SNCV of both groups after treatment were \nsignificantly increased. MNCV, SNCV of mediannerve and nervus peroneus communis in \nstudy group was significantly higher than that in control group. hs-CRP and TCSS scoring \nof both groups before treatment showed no statistic significant difference. hs-CRP scoring of \nboth groups after treatment showed no significant difference. TCSS scoring was significantly \nlower than that in control group. Adverse reaction total occurrence rate after given drug in \nstudy group was 16.67% (7/42), compared with 7.14% (3/42) in control group, difference \nwas significant. Conclusions: Mouse NGF combined with mecobalamine could achieve \ngood curative effect. It is of higher safety in the treatment of patients with DPN, and deserves \npopularization and application.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.092
GPT teacher head0.453
Teacher spread0.361 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2016
Admission routes1
Has abstractyes

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