In vitro Anti-malarial Activity of Rhizome Extracts of Curcuma species
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Anopheles mosquitoes carry the deadly parasite illness malaria, which kills thousands of people annually in many tropical and subtropical areas. This study set out to evaluate the effectiveness of chloroquine in treating Curcuma species malaria caused by Plasmodium vivax. In this investigation, the malaria pathogen Plasmodium vivax was employed. In an incubator with 5% CO2 and 37°C, parasitemia was cultivated in RPMI 1640 culture media supplemented with 10% human serum and 2µg/ml of gentamycin. In order to evaluate plant extracts' ability to combat malaria, we employed the susceptibility micro assay method. Significant parasitaemia inhibitions were demonstrated by ethanolic extracts of Curcuma longa, Hedychium coronarium, and Curcuma caesia against blood stage chloroquine-resistant P. vivax, with low cytotoxic effects to parasitaemia cells in vitro. These inhibitions ranged from 5.8-75.6%, 2.2-29%, and 2-29.8%. The growth of P. vivax, which is resistant to chloroquine, was effectively inhibited by extracts derived from six different plant species. The results supported the fractionation of these plants using a bioassay to identify strong anti-malarial chemicals or to create standardised extracts that could strengthen the anti-malarial impact in vitro
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.021 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it