OAS Gene Family Expression is Associated with Clinical Outcomes in Human Cancers
Bibliographic record
Abstract
Abstract The 2’, 5’-oligoadenylate synthetase (OAS) gene family plays an active role in antiviral immunity. Given their role in apoptosis and autoimmunity, aberrant expression of the OAS genes has been implicated in carcinogenesis. However, there has been minimal investigation of their potential role in tumorigenesis. Therefore, in this study, we used data from publicly available databases to examine the expression pattern of the OAS genes in different cancer tissues compared to normal tissues. The expression of the OAS genes was elevated in ten different cancer types. We observed significant association between the expression level of the OAS genes and overall survival (OS) in adrenocortical carcinoma (ACC), bladder urothelial carcinoma (BLCA), lower grade glioma (LGG), lung adenocarcinoma (LUAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), skin cutaneous melanoma (SKCM), kidney chromophobe (KICH), kidney renal cell carcinoma (KIRC), and thymoma (THYM). We also found interesting correlations between OAS gene expression and clinicopathological features, pathway enrichment, genetic alteration, copy number variations (CNVs), CD8 + T immune cell infiltration, and tumor purity in different cancers. Collectively, our findings indicate the potential utility of using the OAS family both as a diagnostic and prognostic biomarker and a therapeutic target in relevant cancers and contribute valuable insights into the intersection of cancer biology and treatment strategies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".