CO-PILOT: Dynamic Top-Down Point Cloud with Conditional Neighborhood Aggregation for Multi-Gigapixel Histopathology Image Representation
Bibliographic record
Abstract
Predicting survival rates based on multi-gigapixel histopathology images is one of the most challenging tasks in digital pathology. Due to the computational complexities, Multiple Instance Learning (MIL) has become the conventional approach for this process as it breaks the image into smaller patches. However, this technique fails to account for the individual cells present in each patch, while they are the fundamental part of the tissue. In this work, we developed a novel dynamic and hierarchical point-cloud-based method (CO-PILOT) for the processing of cellular graphs extracted from routine histopathology images. By using bottom-up information propagation and top-down conditional attention, our model gains access to an adaptive focus across different levels of tissue hierarchy. Through comprehensive experiments, we demonstrate that our model can outperform all the state-of-the-art methods in survival prediction, including the hierarchical Vision Transformer (ViT), across three datasets and four metrics with only half of the parameters of the closest baseline. Importantly, our model is able to stratify the patients into different risk cohorts with statistically different outcomes across three large datasets, a task that was previously achievable only using genomic information. Furthermore, we publish a large dataset containing 873 cellular graphs from 188 patients, along with their survival information, making it one of the largest publicly available datasets in this context.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.003 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".