Establishing a Correlation of Clinical Characteristics with the Level of Tumor Mutation Burden in Urothelial Bladder Carcinoma
Bibliographic record
Abstract
Bladder cancer is a complex disease and one of the most lethal types of cancer. Recently, some malignancies, including bladder carcinomas, have shown better results with immunotherapy using immune checkpoint inhibitors. Tumor mutational burden (TMB) is a potential biomarker for predicting tumor behavior and immunotherapy response as an outcome. Publicly available clinical data from the bladder cancer of TCGA project is used to analyze correlations of clinical variables with an increased tumor mutation burden (TMB) number compared with those with a lower number of mutations. The threshold for the high mutation burden in the analysis was set at 10 mutations (Mut) per Megabase (Mb). The Chi-Square test (χ2) was used to compare categorical data. The Chi-Square "Best first" method was used to find a correlation between clinical variables and TMB, then compared with the p-value of significance (p<0.05). A significant correlation was found between TMB and Race, Neoplasm Histologic Grade, and gender when applying the Best First/Chi-Square method to clinical variables and level of TMB. This enables further investigation and application of the prediction models of the level of TMB, responsiveness to immunotherapy, and prognosis based on the clinical features of the patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".