P1107 Clinical characteristics and prognosis of very young adult-onset Crohn's disease: Results from the Prospective CONNECT Study
Bibliographic record
Abstract
Abstract Background Although the A2 group according to the Montreal classification accounts for the largest proportion among patients with Crohn’s disease (CD),1 there has been a lack of studies comparing the clinical characteristics and prognosis according to the age at diagnosis within the A2 group. Methods We utilised data from the prospective CONNECT study—a nationwide, multicentre cohort study of CD patients in Korea.2 Of 1,175 participants, a total of 945 patients (80.4%) were categorised as Montreal classification of age A2 (≥17 and <40 years at diagnosis). They were further divided into two groups based on the age at diagnosis: very young adult-onset group (≥17 and <20 years, n=275) and young adult-onset group (≥20 and <40 years, n=670). Results Isolated ileal diseases were more common in the young adult-onset group (21.5% vs. 30.7%), whilst the frequency of stricturing (B2) or penetrating (B3) behaviours was tended to be lower in the very young adult-onset group than in the young adult-onset group (16.7% vs. 29.7%) (Table 1). Twenty-five patients (9.1%) in the very young adult-onset group underwent intestinal resection compared to 91 patients (13.6%) in the young adult-onset group (p=0.072). The very young adult-onset group had a longer intestinal resection-free survival than the young adult-onset group (p=0.04) (Figure 1a). More patients in the very young adult-onset group received systemic corticosteroids compared with those in the young adult-onset group (62.2% vs. 48.8%, p<0.001) and the corticosteroid-free survival was shorter in the very young adult-onset group compared with the young adult-onset group (p<0.01) (Figure 1b). Complicated behaviors (B2, adjusted hazard ratio [aHR] 4.03, 95% confidence interval [CI] 2.42–6.70, p<0.001; B3, aHR 6.39, 95% CI 4.21–9.72, p<0.001) was independently associated with the risk of intestinal resection. Conclusion The very young adult-onset group exhibited distinct disease behaviour at diagnosis and different clinical outcomes compared with the young adult-onset group. Within the A2 group (≥17 and <40 years at diagnosis), the risk of intestinal resection appears to be driven by the intestinal complications. References 1. Silverberg MS, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005;19 Suppl A:5A–36A. 2. Hong SW, et al. Clinical features and long-term prognosis of Crohn's disease in Korea: Results from the Prospective CONNECT Study. Gut Liver 2022;16(6):907–920. Financial support: This work was supported by the Research Program funded by the Korea Disease Control and Prevention Agency (2022ER050400).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".