Personality change and associated factors in patients with mild cognitive impairment (P. 39)
Bibliographic record
Abstract
Background: Previous studies have shown that a history of personality change might guide the diagnosis of early mild cognitive impairment (MCI), which would lead to earlier treatment and better outcome of dementia.Objectives: To investigate personality change and other factors associated with MCI.Methods: This cross-sectional descriptive study was conducted by recruiting information from 83 patients with MCI at King Chulalongkorn Memorial Hospital using Thai version of questionnaires about demographic data, the Thai Mental State Examination (TMSE), the Montreal Cognitive Assessment (MoCA), the Thai Geriatric Depression Scale, the Neuropsychiatric Inventory Questionnaire (NPI-Q) and the International Personality Item Pool (IPIP).The patients' caregivers were also asked to evaluate the patients' personality during the 5 years prior to the diagnosis and their current personality.The statistical analyses were frequency, percentage, mean and t -test.Analysis of factors correlated with personality change was performed with logistic regression.Results: Eighty-three patients were included, showing a mean age of 72.1 7.1 years old with 61.4% of them being female.The mean TMSE was 27.6 1.9 and the mean MoCA was 21.6 3.1.Personality change in patients with MCI showed a statistically significant increase in neuroticism and a decrease in openness to experience, agreeableness and conscientiousness (P < 0.05).There was a negative correlation between emotional stability, agreeableness, and NPI-Q (r = -0.442and -0.227) (P < 0.001 and P = 0.039).A positive correlation between extraversion and MoCA was found (r = 0.336) (P = 0.002).Neuroticism was detected to have a correlation with neuropsychiatric symptoms (NPS), including irritability, anxiety, depression, apathy, disinhibition, and agitation.There was a significant correlation between agreeableness and NPS (apathy) (P < 0.05).Conclusions: Our findings suggest that there was personality change in MCI patients, featuring an increase in neuroticism, openness to experience, and agreeableness and a decrease in extraversion and conscientiousness.Extraversion was found to be positively correlated with cognitive functions and there was a positive and negative correlation with NPS among neuroticism and agreeableness, respectively.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".