Correlation of UniPolar Electrogram modification with Ablation Index during Atrial Fibrillation ablation: a pilot study ( COUPE–AF)
Bibliographic record
Abstract
Introduction Pulmonary vein isolation using radiofrequency catheter ablation is the standard of care for patients with drug-refractory atrial fibrillation. The purpose of this pilot study was to examine the local unipolar electrogram (UEGM) modification characteristics of the different target areas of left atrium and the associated ablation index parameters during pulmonary vein isolation procedure. Methods The study analyzed ten patients who underwent pulmonary vein isolation using radiofrequency energy at our Centre in 2021. The local electrophysiological properties and ablation parameters of 15 designated areas of interest in the left atria targeted by radiofrequency catheter ablation were collected. Results Out of the ten patients, six were men (mean age 66 years) and the majority (n=8) had paroxysmal atrial fibrillation. UEGM modification was observed in every studied RF ablation lesion. The mean time to achieve the UEGM modification in the posterior wall was shorter than that of the anterior wall( 8.9 seconds vs 11.1 seconds, respectively). The time to achieve the UEGM modification for every target was significantly shorter than delivered ( p<.001). Conclusion This study demonstrated that during pulmonary vein isolation using radiofrequency energy, local UEGM modification, representing a real-time surrogate of transmural lesion creation, is achieved in significantly shorter time reaching the conventional Ablation Index-guided approach in current practice.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".