Epidermolysis bullosa acquisita: diagnostic difficulties
Bibliographic record
Abstract
described, the mechanobullous and inflammatory [7].The mechanobullous form of EBA, which represents the majority of cases, has a chronic course, and bullous eruptions occur in the mechanical trauma-prone areas such as the extensor surfaces of the limbs, elbows, knees, hands, feet and buttocks [4,6].Skin lesions may be accompanied by scarring alopecia and nail dystrophy [8].The inflammatory variant is characterised by sudden onset, and skin lesions are not limited to injured areas.EBA also includes bullous pemphigoid (BP), mucous membrane pemphigoid (MMP), linear IgA dermatosis (LABD) and Brunsting-Perry variants.However, two variants of EBA may occur in one patient [7].Diagnosis of EBA is based on direct immunofluorescence (DIF) with serration pattern analysis and/or detection of serum autoantibodies against type VII collagen (anti-CO7 antibodies) [9].EBA is mainly treated with high doses of glucocorticosteroids.Other therapeutic options involve dapsone, cyclosporine, AbstrAct Introduction: Epidermolysis bullosa acquisita is a blistering disease in which the autoimmune response is directed against collagen VII epitopes.Case report: A 50-year-old patient was admitted to the Department due to erythematous erosions and single blisters.The direct immunofluorescence study from a perilesional biopsy showed in vivo bound linear IgG deposits and focal C3 along the dermal-epidermal junction; however, the characteristic u-serrated pattern was not observed.No circulating antibodies were found in the serum.The direct immunofluorescence study performed on salt-split skin revealed immune deposits located along the floor and focally within the roof of the artificial blister.To determine the final diagnosis, type VII collagen was mapped on patient's salt-split skin using double-labelling with anti-collagen VII antibodies and serum from a seropositive epidermolysis bullosa acquisita patient.The overlapping of the identical images was obtained.Conclusions: Marking the distribution of collagen VII on salt-split skin enabled the diagnosis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.019 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.006 | 0.003 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.003 | 0.006 |
| Open science | 0.003 | 0.002 |
| Research integrity | 0.004 | 0.008 |
| Insufficient payload (model declined to judge) | 0.005 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".