"Association of the K-RAS Gene Mutation with Gallbladder Cancer"
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The early development of gallbladder cancer is usually asymptomatic and has a high tendency to metastatic spread, so most patients are diagnosed in intermediate to advanced stages.The role of various genetic mutations is a currently active field of research that has sometimes transformed the diagnosis and/or treatment of some types of cancer.The point mutation in codon 12 of the K-ras gene has become the target of analysis in different studies, because there is considerable debate about the frequent presence of this mutation in malignant lesions of the gallbladder.Therefore, demonstrating whether there is a significant association through an analytical study could be useful to offer a useful molecular diagnostic marker in the detection of the early stage of carcinogenesis in the gallbladder and reduce a public health problem.This meta-analysis was performed through a systematic search using the PubMed and EBSCO library databases, where 10 studies with a total of 221 cases and 163 controls were selected.Publication bias was assessed using the GRADE approach and the quality of each study was assessed independently using the Newcastle-Ottawa Assessment Scale.Epi-data version 3.1 software was used to assess this association, where our results demonstrated a significant association between the mutation of codon 12 of the K-ras gene and the risk of gallbladder cancer (OR: 0.18; IC 95%: 0.08-0.41).The P value of the Q test was: 0.32.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.007 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.004 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it