Proceedings of the 27th International Stroke Genetics Consortium Workshop
Bibliographic record
Abstract
The ISGC is an international collaboration of physicians and scientists who have agreed to pool resources and expertise in an effort to unravel the genetic basis of stroke and its comorbidities.Founded in 2007 by a small group of stroke genetics investigators, the ISGC has grown to over 200 members representing over 50 countries in North and South America, Europe, Australia, Africa, and Asia.ISGC workshops are held semi-annually and provide a forum for ISGC investigators to report on progress of ongoing scientific projects and discuss new ideas that help advance the ISGC's research mission.The ISGC nurtures junior investigators by offering several travel awards to young investigators interested in stroke genetics.Many abstracts in these Proceedings reflect the contributions of active junior investigators.Herein, we present the Proceedings and official published abstracts of the 27th ISGC Workshop.Presentations at the workshop included invited lectures, ISGC working group reports, and short presentations about ongoing research projects and new collaborative proposals.Invited speakers, contributing in the areas of cross-ancestry approaches to stroke genetics, large biobank initiatives, rare genetic variants, imaging tools for cerebrovascular genomics and genetic contributions to drug discovery, included Ananyo Choudhury (University of the Witwatersrand), on cutting-edge genetic studies in African populations; Elisabeth Tournier-Lasserve (Paris Cité University), one of the world's lead experts of monogenic diseases affecting cerebral small vessels; Michel Thiébaut de Schotten (University of Bordeaux), an international expert in neuroimaging and connectomics; and Vincent Mooser (McGill University), holder of the Canada excellence research chair in genomic medicine and expert in drug discovery and precision drug development.The ISGC actively invites other like-minded collaborative scientists to join the consortium.The next Workshops will be held in Melbourne, Australia in March 2023.We encourage you to visit our website (strokegenetics.org)for further details.On behalf of the ISGC Steering Committee and its many members, we hope that you enjoy reviewing these Proceedings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.010 | 0.008 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.008 | 0.002 |
| Open science | 0.002 | 0.006 |
| Research integrity | 0.004 | 0.005 |
| Insufficient payload (model declined to judge) | 0.075 | 0.029 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".