Pericytes express markers of cellular proliferation without expansion of the pool in response to exercise-induced skeletal muscle damage
Bibliographic record
Abstract
Muscle-resident stromal cells, known as pericytes, have been shown to support muscle repair and/or regeneration. However, the extent to which pericytes respond during skeletal muscle repair in humans remains relatively unknown. The purpose of this study was to evaluate the pericyte response following damage-inducing eccentric muscle contractions. Healthy, young men (21.5 ± 0.5 years, n = 22), performed maximal muscle lengthening contractions via an isokinetic dynamometer. Muscle biopsies from the vastus lateralis were taken at baseline (Pre) and, 6 h-, 24 h-, 72 h-, 96 h following exercise-induced damage. Muscle-resident NG2 + pericyte content remained unchanged over time (p > 0.05), but the number of pericytes actively proliferating (Ki67 + /NG2 + ) was significantly (p < 0.05) elevated 24 h following damage. NG2 protein and associated mRNA expression of CSPG4 were significantly (p < 0.05) increased 24 h post-exercise. mRNA expression of signaling factors, related to pericyte mobility and activation including TNFa , CD248 and CXCR4 were significantly upregulated at 24 h post-exercise (p < 0.05). Taken together, muscle injury promotes the upregulation of nuclear proteins associated with proliferation of NG2 + pericytes and increases pericyte associated mRNA expression.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".