Perturbations in Risk/Reward Decision Making and Frontal Cortical Catecholamine Regulation Induced by Mild Traumatic Brain Injury
Bibliographic record
Abstract
Abstract Mild traumatic brain injury (mTBI) can disrupt cognitive processes that influence risk taking behavior. Athletes, military personnel, and domestic violence victims often experience multiple mTBIs; however, little is known regarding the effects of repetitive injury (rmTBI) on risk/reward decision making or whether these outcomes are sex specific. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is composed of several sub-regions including the medial PFC (mPFC), anterior cingulate cortex (ACC), and orbitofrontal cortex (OFC). These regions are densely innervated by catecholaminergic fibers, which modulate PFC-mediated cognitive processes. Aberrant catecholamine activity within the PFC has been documented following TBI, which may underlie TBI-induced risky behavior. Tyrosine hydroxylase (TH) and norepinephrine transporter (NET) regulate catecholamine homeostasis within the PFC; however, it has not been determined how rmTBI affects these proteins. The present study aimed to characterize the effects of rmTBI on risk/reward decision making behavior and catecholamine transmitter regulatory proteins within the PFC. Risk/reward decision making was evaluated using a probabilistic discounting task (PDT) which required rats to choose between small/certain rewards delivered with 100% certainty and large/risky rewards delivered with decreasing probabilities over a session. Rats were first trained on the PDT and then exposed to sham, single (smTBI), or a series of three closed-head control cortical impact (CH-CCI) injuries over the course of one week, followed by four weeks of PDT testing. In week 1 post-final surgery, mTBI generally enhanced preference for the larger/riskier option with these effects seemingly more prominent in females. These effects resolved by week 2 post-final surgery indicating that the effects of mTBI on choice behavior are transient. By week 4, males, but not females, exhibited increased latencies to make riskier choices following rmTBI, demonstrating a delayed effect of injury on information processing speed. A separate group of rats was used to measure changes in levels of TH and NET within the mPFC, ACC, and OFC forty-eight hours after mTBI. No injury-induced differences were observed within the mPFC or ACC. In the OFC, females exhibited dramatic increases in TH levels following smTBI, but only small increases following rmTBI. Both males and females; however, experienced reduced levels of NET following rmTBI, which may function as a compensatory response to increased extracellular levels of catecholamines. Together, these results suggest that OFC is more susceptible to catecholamine instability after rmTBI, a finding indicating that not all areas of the PFC contribute equally to the observed TBI-induced catecholamine imbalances. Overall, combining the CH-CCI model of rmTBI with the PDT proved effective in revealing time-dependent and sex-specific changes in risk/reward decision making and catecholamine regulation following repetitive mild head injuries.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".