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Record W4392295378 · doi:10.31080/asms.2024.08.1775

Cardiolipin Antibodies in Biopsy-defined Adult Celiac Disease

2024· article· en· W4392295378 on OpenAlexaff
Hugh James Freeman

Bibliographic record

VenueActa Scientific Medical Sciences · 2024
Typearticle
Languageen
FieldMedicine
TopicCeliac Disease Research and Management
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsCardiolipinMedicineAntibodyBiopsyDiseaseImmunologyInternal medicinePathologyBiologyBiochemistry

Abstract

fetched live from OpenAlex

Cardiolipin antibodies have been considered to be a hallmark or marker of the antiphospholipid syndrome, a disorder associated with an increased risk of cerebrovascular events and pregnancy loss.Prior studies have shown increased cardiolipin antibodies in celiac disease, and even higher in some studies of treated celiac disease with a gluten-free diet.Still, limited clinical follow-up in these studies did not permit exploration of an increased risk of cardiovascular events.This study explored this paradigm in 28 celiac disease patients, treated with a gluten-free diet, defined by histopathological evidence of normalization of small intestinal mucosa.Here, in celiacs on a lifelong gluten-free diet, no increased cardiovascular risk, as reflected in clinically evident thrombotic or embolic events, was identified despite follow-up for up to 34 years.Cardiolipin antibodies in gluten-free diet treated celiac disease could represent a marker of risk, but this was defined here despite long-term clinical follow-up over many decades.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.204
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0000.002
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.351
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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