Development and Validation of a RP-HPLC Method for Simultaneous Quantification of Paracetamol and Phenylephrine Hydrochloride
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Bibliographic record
Abstract
A rapid, accurate, and sensitive method for the simultaneous quantification of paracetamol and phenylephrine hydrochloride was developed using RP-HPLC.The procedure utilized a NUCLEODUR® C18 separating column (250 × 4.6 mm id) with a flow rate of 0.8 mL/min and a column temperature of 25℃.The detector wavelength was set at 234 nm, and the injection volume was 20 μL.The mobile phase consisted of a mixture of acetonitrile and buffer solution (45 mM orthophosphoric acid, and the pH was adjusted to 6 using a 10% (w/v) sodium hydroxide solution) in a 52:48 v/v ratio.The method was validated with recovery percentages ranging from 99.36 to 105% for paracetamol and 99.78 to 100.8% for phenylephrine.The correlation coefficients were 0.9999 for both compounds, with linearity ranges of 2-100 µg/mL for paracetamol and 5-80 µg/mL for phenylephrine.This method has been successfully applied to the simultaneous quantification of these drugs in pharmaceutical preparations available in the local market.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it