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Record W4392367571 · doi:10.21203/rs.3.rs-3936426/v1

The effects of modified deep serratus anterior plane block on surgical stress and perioperative neurocognitive disorders in elderly patients undergoing thoracic surgery: a randomized clinical study

2024· preprint· en· W4392367571 on OpenAlexaboutno aff
Jiating Cheng, Qirui Sun, Jianliang Sun, Yuan Cheng, Weiping Lei

Bibliographic record

VenueResearch Square · 2024
Typepreprint
Languageen
FieldMedicine
TopicIntensive Care Unit Cognitive Disorders
Canadian institutionsnot available
FundersScience and Technology Program of Zhejiang ProvinceMedical Science and Technology Project of Zhejiang Province
KeywordsPerioperativeNeurocognitiveMedicineSurgerySurgical stressRandomized controlled trialAnesthesiaCognitionPsychiatry

Abstract

fetched live from OpenAlex

Abstract Background To evaluate and compare the effects of a modified deep serratus anterior plane block (DSPB) combined with general anesthesia on surgical stress and perioperative neurocognitive disorder (PND) in elderly patients undergoing thoracic surgery, providing a new way to reduce the occurrence of PND in elderly patients undergoing thoracic surgery. Methods Sixty-six patients undergoing thoracic surgery were randomly assigned to receive either single-shot DSPB or local block after tracheal intubation using ropivacaine 0.5% 20 mL. The primary outcomes were the visual analog scale (VAS) score at each time point and the Montreal cognitive assessment (MoCA) score before surgery and after discharge from the hospital (or seventh day postoperative). Secondary outcomes included drug consumption, vital signs, blood gas analysis, malondialdehyde, superoxide dismutase, and serum cortisol levels. Results Sixty patients were eventually enrolled in this study. The VAS scores were significantly lower in the DSPB group than in the local block group (all P < 0.05). The difference in blood gas analysis index TCO2 (27.71 ± 3.49 vs 29.31 ± 2.26) in the two groups was statistically significant (P < 0.05). The length of hospitalization in the DSPB group was shorter than that in the local block group (6.03 ± 1.35 vs 7.20 ± 1.49), and the difference was statistically significant (P < 0.05). There were no statistically significant differences in MoCA scores before surgery and after hospitalization (or the seventh day postoperative), stress indices, vital signs, bispectral index value, blood gas analysis (except TCO2), and drug addiction during extubation at each time point (all P > 0.05). Conclusion Compared with local block, DSPB provided a superior analgesic effect with a lower VAS score and shorter length of hospitalization in elderly ptalatients undergoing thoracic surgery. It does not require ultrasound equipment, making it simpler and easier to operate, and is especially suitable for widespread implementation in grassroots hospitals.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.405
Teacher spread0.373 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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