Vitamin B12 Status Among Patients With Type 2 Diabetes Mellitus
Bibliographic record
Abstract
Background: Vitamin (vit.) B12 is a vital nutrient for ideal hemopoietic, neurocognitive, and cardiovascular integrity. The frequency of vit. B12 abnormalities in patients with type 2 diabetes mellitus (T2DM), especially with the chronic use of metformin, has been demonstrated and verified. In this study, the levels of vit. B12 and its metabolites in metformin-using T2DM participants were measured and compared to healthy participants to conclude any causal relationship. Methods: The study was conducted on selected T2DM patients who are using a high dose of metformin for the long term and compared to healthy volunteers regarding the following parameters: body mass index (BMI), waist circumference, complete blood cell (CBC), serum homocysteine, methylmalonic acid, transcobalamin, and holo-transcobalamin. SPSS was used for data analysis, implementing the unpaired Students t -test and the Chi-square test for significance. Results: Levels of holo-transcobalamin and homocysteine were insignificantly higher in T2DM patients. However, transcobalamin was insignificantly higher in the test group, while methylmalonic acid was surprisingly below the normal levels among both groups. No significant difference in BMI was reported between both groups, but T2DM patients had significantly higher waist circumferences compared to their healthy counterparts. Conclusions: The study showed high homocysteine levels in T2DM patients, consistent with the literature of similar studies of vit. B12 deficiency. However, it also showed unexplained reduced levels of methylmalonic acid and unexpectedly high levels of transcobalamin and homo-transcobalamin in the T2DM patients compared to the control group. These results indicate additional investigations are needed using a larger sample size of both groups to reach a meaningful conclusion. J Endocrinol Metab. 2024;14(1):33-39 doi: https://doi.org/10.14740/jem928
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".