Improved lung function is associated with better asthma control in children aged 6 to 11 years with moderate-to-severe type 2 asthma: A post hoc analysis of VOYAGE
Bibliographic record
Abstract
Hintergrund In patients treated with biologics, evidence of the impact of lung function improvement on patient reported outcomes is limited. In VOYAGE (NCT02948959), dupilumab significantly reduced asthma exacerbations and improved lung function and asthma control in children (6 to 11 years) with uncontrolled, moderate-to-severe asthma, with an acceptable safety profile. This post hoc analysis evaluated the association between lung function improvements and asthma control in this population. Methoden Children with moderate-to-severe type 2 asthma (baseline blood eosinophil count ≥150 cells/μL or FeNO ≥20 ppb) received add-on dupilumab 100/200 mg q2w (by bodyweight), or placebo for 52 weeks. They were stratified according to low, medium, or high tertile subgroups based on the change from baseline in pre-bronchodilator percent predicted forced expiratory volume in 1 second [ppFEV 1 ] at Week 52 in pooled dupilumab and placebo treatment arms. Using a logistic regression model adjusted for baseline characteristics, we compared the proportion of children with well-controlled asthma (Interviewer-Administered 5-item Asthma Control Questionnaire [ACQ-5-IA] score ≤ 0.75) at Week 52 between tertile subgroups. Ergebnisse Mean (SD) change from baseline in pre-bronchodilator ppFEV 1 was −6.87 (8.92), 7.52 (3.25), and 26.89 (16.04) percentage points in the low (n=102), medium (n=109), and high (n=110) tertile subgroups, respectively. Greater proportions of children achieved well-controlled asthma in the medium (77%) and high (78%) tertile subgroups compared with the low tertile subgroup (64%, both P<0.001). Schlussfolgerung In children with type 2 asthma, greater lung function improvements were associated with better asthma control in the pooled dupilumab and placebo treatment arms. Publication History Article published online: 22 February 2024 © 2024. Thieme. All rights reserved. Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, Germany
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.007 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".