The mediating role of coagulation factor VIII in the effect of chronic inflammation on recurrent thrombotic events in children with non-central line deep vein thrombosis
Bibliographic record
Abstract
Introduction Pediatric patients who had a first venous thromboembolic event are at risk of experiencing a thrombosis recurrence, which in turn is associated with high morbidity and mortality. Thus, predicting recurrence is relevant for clinical management. In a previous study, we have shown that chronic inflammation independently predicted recurrent thrombotic events in children with an index non-central venous catheter (non-CVC) related deep vein thrombosis (DVT). In that study, coagulation factor VIII (FVIII) did not predict thrombosis recurrence. However, FVIII is an acute phase protein that can be increased in the context of inflammatory conditions. Therefore we investigated the extent to which the effect of chronic inflammation on the outcome of thrombosis recurrence is mediated by FVIII.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".