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Record W4392757422 · doi:10.1080/15548627.2024.2319901

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

2024· review· en· W4392757422 on OpenAlexaff
Xin Chen, Andrey S. Tsvetkov, Han‐Ming Shen, Ciro Isidoro, Nicholas T. Ktistakis, Andreas Linkermann, Werner J.H. Koopman, Hans‐Uwe Simon, Lorenzo Galluzzi, Shouqing Luo, Daqian Xu, Wei Gu, Olivier Peulen, Qian Cai, David C. Rubinsztein, Jen‐Tsan Chi, Donna D. Zhang, Changfeng Li, Shinya Toyokuni, Jinbao Liu, Jong‐Lyel Roh, Enyong Dai, Gábor Juhász, Wei Liu, Jianhua Zhang, Minghua Yang, Jiao Liu, Ling‐Qiang Zhu, Weiping Zou, Mauro Piacentini, Wen Y. Ding, Zhenyu Yue, Yangchun Xie, Morten Petersen, David A. Gewirtz, Michael A. Mandell, Charleen T. Chu, Debasish Sinha, Eftekhar Eftekharpour, Boris Zhivotovsky, Sébastien Besteiro, Dmitry I. Gabrilovich, Do‐Hyung Kim, Valerian E. Kagan, Hülya Bayır, Guang‐Chao Chen, Scott Ayton, Jan D. Lünemann, Masaaki Komatsu, Stefan Krautwald, Ben Loos, Eric H. Baehrecke, Jiayi Wang, Jon D. Lane, Junichi Sadoshima, Wan Seok Yang, Minghui Gao, Christian Münz, Michael Thumm, Martin Kampmann, Di Yu, Marta M. Lipinski, Jace W. Jones, Xuejun Jiang, Herbert J. Zeh, Rui Kang, Daniel J. Klionsky, Guido Kroemer, Daolin Tang

Bibliographic record

VenueAutophagy · 2024
Typereview
Languageen
FieldMedicine
TopicFerroptosis and cancer prognosis
Canadian institutionsUniversity of Manitoba
FundersNational Cancer InstituteLabex Immuno-OncologyBiotechnology and Biological Sciences Research CouncilInstitut National Du CancerInstitut Universitaire de FranceNational Institute of General Medical SciencesLigue Contre le CancerFondation pour la Recherche MédicaleNational Natural Science Foundation of ChinaAgence Nationale de la RechercheUniversité de ParisSeerave FoundationAssociation pour la Recherche sur le CancerEuropean CommissionCentre National de la Recherche ScientifiqueNational Institutes of HealthEquipex
KeywordsBiologyAutophagyInterpretation (philosophy)Computational biologyGeneticsComputer scienceApoptosis

Abstract

fetched live from OpenAlex

: 3-MA:3-methyladenine; 4HNE: 4-hydroxynonenal; ACD: accidentalcell death; ADF: autophagy-dependentferroptosis; ARE: antioxidant response element; BH2:dihydrobiopterin; BH4: tetrahydrobiopterin; BMDMs: bonemarrow-derived macrophages; CMA: chaperone-mediated autophagy; CQ:chloroquine; DAMPs: danger/damage-associated molecular patterns; EMT,epithelial-mesenchymal transition; EPR: electronparamagnetic resonance; ER, endoplasmic reticulum; FRET: Försterresonance energy transfer; GFP: green fluorescent protein;GSH: glutathione;IF: immunofluorescence; IHC: immunohistochemistry; IOP, intraocularpressure; IRI: ischemia-reperfusion injury; LAA: linoleamide alkyne;MDA: malondialdehyde; PGSK: Phen Green™ SK;RCD: regulatedcell death; PUFAs: polyunsaturated fatty acids; RFP: red fluorescentprotein;ROS: reactive oxygen species; TBA: thiobarbituricacid; TBARS: thiobarbituric acid reactive substances; TEM:transmission electron microscopy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.013
metaresearch head score (Gemma)0.012
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.068

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0130.012
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.004
Bibliometrics0.0080.004
Science and technology studies0.0010.002
Scholarly communication0.0030.002
Open science0.0050.002
Research integrity0.0040.004
Insufficient payload (model declined to judge)0.0080.006

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.125
GPT teacher head0.401
Teacher spread0.275 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations176
Published2024
Admission routes1
Has abstractyes

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