O7 High incidence of both spontaneous and indicated preterm birth in women with systemic lupus erythematosus: a systematic review and meta-analysis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
<h3>Objective</h3> Preterm birth (PTB) is a frequent complication of pregnancy in women with systemic lupus erythematosus (SLE). The high indicated PTB rate due to hypertensive disorders of pregnancy and/or fetal growth restriction in women with SLE is well known. Preventive measures are taken and screening for early detection are performed, but the risk of spontaneous PTB is less well recognized. The objective of this study is to determine the rates of both spontaneous and indicated PTB in pregnancies of women with SLE. <h3>Methods</h3> A systematic literature search using Pubmed, Embase, Web of Science and Google Scholar was performed in June 2021. Studies on pregnant women with SLE reporting spontaneous and indicated PTB (birth <37 weeks) rates were selected. Original research articles in English published from 1995 to June 2021 were included. Quality and risk of bias of the included studies were assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). To estimate the pooled event rates and 95% confidence intervals, meta-analyses of single proportions with a random-effects model were performed. <h3>Results</h3> We included 21 articles, containing data of 8157 ongoing pregnancies in women with SLE. Fifteen out of the 21 included studies were of good quality according to the NOS. From the ongoing pregnancies, 31% (95% CI [0.26; 0.35]) resulted in PTB, of which 46% (95% CI [0.39; 0.54]) were spontaneous, and 53% (95% CI [0.44; 0.61]) were indicated; in 1% the cause of PTB was unknown. The incidence of spontaneous PTB in all pregnancies was 14% (95% CI [0.11; 0.16]) and of indicated PTB 16% (95% CI [0.12; 0.19]). <h3>Conclusion</h3> In pregnant women with SLE, spontaneous as well as indicated PTB rates are high. This information should be applied in (pre-pregnancy) counselling and management in pregnancy. The knowledge obtained by this review and meta-analysis paves the way for further research of associated risk factors and development of interventions to reduce spontaneous PTB rate in SLE pregnancies. <h3>Funding</h3> None.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.011 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it