Legislation and oversight of the conduct of research using animals: a global overview
Bibliographic record
Abstract
This chapter discusses the key aspects of laws, regulations, policies and/or codes that apply to the use of animals in biomedical research and testing. It describes some of the similarities and distinctions between countries/regions where biomedical research is conducted by describing the regulatory climate and systems of oversight in several countries. An institution-based process is the commonest method of animal activity evaluation and authorisation around the world. The Animal Welfare Body, required by the Directive in all establishments, play an important role in oversight activities of the programme. The Canadian Constitution precludes federal legislation pertaining to the use of animals in research, testing or education, and as a result such use is under provincial jurisdiction. In 1978, the Food and Drug Administration initially promulgated regulations for the conduct of animal research on new or existing pharmaceutical agents, food additives or other chemicals.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.006 | 0.009 |
| Science and technology studies | 0.002 | 0.005 |
| Scholarly communication | 0.006 | 0.005 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.003 | 0.004 |
| Insufficient payload (model declined to judge) | 0.006 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".