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Record W4392928363 · doi:10.25251/skin.8.supp.396

Bimekizumab Response Maintenance to 48 Weeks in Patients with Moderate to Severe Hidradenitis Suppurativa: Pooled Responder Analysis from the Phase 3, Double-Blind, Placebo-Controlled, Randomized Clinical Trials BE HEARD I and II

2024· article· en· W4392928363 on OpenAlexfundno aff
John R Ingram, Martina L. Porter, Raj Chovatiya, Evangelos J. Giamarellos‐Bourboulis, Falk G. Bechara, Hideki Fujita, Wayne Gulliver, Edward Muller, Muhammad Bari, Robert Rolleri, Rob Byerly, Joslyn S. Kirby

Bibliographic record

VenueSKIN The Journal of Cutaneous Medicine · 2024
Typearticle
Languageen
FieldMedicine
TopicHidradenitis Suppurativa and Treatments
Canadian institutionsnot available
FundersDaiichi Sankyo EuropeUCB PharmaBausch HealthSwedish Orphan BiovitrumNational and Kapodistrian University of AthensInsmedEisaiCelltrionXBiotechCelgeneAmgenPfizerEli Lilly and CompanyGaldermaIncyte
KeywordsHidradenitis suppurativaMedicinePlaceboDouble blindRandomized controlled trialClinical trialSingle blindInternal medicinePooled analysisMeta-analysisAlternative medicineDiseasePathology

Abstract

fetched live from OpenAlex

N/A

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.006
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.034

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0060.005
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0060.008
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.041
GPT teacher head0.378
Teacher spread0.337 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

Explore more

Same venueSKIN The Journal of Cutaneous MedicineSame topicHidradenitis Suppurativa and TreatmentsFrench-language works237,207