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TIF1-gamma IgG2 isotype is not associated with malignancy in juvenile dermatomyositis patients
Huong D. Nguyen, F. Jouen, Benoît Déchelotte, N. Cordel, Cyril Gitiaux, Christine Bodemer, Pierre Quartier, Alexandre Bélot, Kathryn O’Brien, Dario Cancemi, Isabelle Melki, Nicole Fabien, Sarah Tansley, Olivier Boyer, Lucy R. Wedderburn, Brigitte Bader‐Meunier, Kate Armon, Louise Coke, Julie Cook, Amy Nichols, Liza McCann, Ian Roberts, Eileen Baildam, Louise Hanna, Olivia Lloyd, Susan Wadeson, Michelle Andrews, Phil Riley, Ann McGovern, Verna Cuthbert, Clive Ryder, J Scott, Beverley Thomas, T. R. E. Southwood, Eslam Al-Abadi, Ruth Howman, Sue Wyatt, Gillian Jackson, Mark Wood, Tania Amin, Vanessa VanRooyen, Deborah Burton, Louise Turner, Heather Rostron, Sarah Hanson, Joyce Davidson, Janet Gardner‐Medwin, Neil A. Martin, Sue A. Ferguson, Liz Waxman, Michael Browne, Roisin Boyle, Emily Blyth, Mark Friswell, Helen Foster, Sharmila Jandial, V. Stevenson, Debbie Wade, Ethan S Sen, Eve Smith, Stuart Watson, Claire Duong, Stephen Crulley, Andrew J. Davies, Miss Caroline Miller, Lynne Bell, Flora McErlane, Sunil Sampath, Sharon King, H Venning, Satyapal Rangaraj, Elizabeth Stretton, Mary Jordan, Ellen Mosley, Lindsay Crate, Kishore Warrier, Stefanie Stafford, Brogan Wrest, Clarissa Pilkington, Nathan Hasson, Muthana Al-Obadi, Giulia Varnier, Sandrine Lacassagne, Sue Maillard, Lauren E. Stone, Elizabeth Halkon, Virginia Brown, Audrey Juggins, Sally A. Smith, Sian Lunt, Elli Enayat, Hemlata Varsani, Laura Kassoumeri, Laura Beard, Katie Arnold, Yvonne Glackin, Stephanie Simou, Beverley Almeida, Kiran Nistala, Raquel Marques, Claire T. Deakin, Parichat Khaosut, Stefanie Dowle, Charalampia Papadopoulou, Shireena A. Yasin, Christina Boros, Meredyth Wilkinson, Christopher Piper, Cerise Johnson-Moore, Lucy Marshall, Emily Robinson, Dominic Igbelina, Polly Livermore, Socrates Varakliotis, Rosie Hamilton, Kevin Murray, Coziana Ciurtin, J Ioannou, Caitlin Clifford, Linda Suffield, Laura Hennelly, Helen Lee, Helen Smith, Anne-Marie McMahon, Heather Chisem, Jeanette Hall, Amy Huffenberger, Nick Wilkinson, Emma Inness, E. J. C. Kendall, Ruth Etherton, Danielle Miller, Kathryn Bailey, Jacqui Clinch, Natalie Fineman, Helen Pluess-Hall, Suzanne Sketchley, Melanie Marsh, Anna Fry, Maisy Dawkins-Lloyd, Manija Asif, Margaret Connon, Lindsay Vallance, Kirsty Haslam, Charlene Bass-Woodcock, Trudy Booth, Louise Akeroyd, Alice Leahy, Amy Collier, Rebecca Cutts, E. J. MacLeod, Hans de Graaf, Brian Davidson, Sarah Hartfree, Elizabeth Fofana, Lorena Caruana
Bibliographic record
VenueLara D. Veeken · 2024
Typeletter
Languageen
FieldMedicine
TopicInflammatory Myopathies and Dermatomyositis
Canadian institutionsInstitute of Infection and Immunity
FundersNIHR Sheffield Biomedical Research CentreMedical Research CouncilVersus ArthritisUniversity of OxfordUniversity College LondonArthritis Research UKAction Medical ResearchNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer ResearchArgenxMyositis AssociationNational Institute for Health and Care ResearchUniversity Hospital Southampton NHS Foundation TrustAgence Nationale de la RechercheWellcome TrustDepartment of Health and Social CareCSL BehringHospital for Sick ChildrenPfizer
KeywordsJuvenile dermatomyositisDermatomyositisIsotypeMalignancyMedicineAntibodyImmunologyDermatologyInternal medicineMonoclonal antibody
Abstract
International audience
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesResearch integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.330
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.010
GPT teacher head0.227
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
Study designNot applicable
Domainnot available
GenreCommentary
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations7
Published2024
Admission routes2
Has abstractyes